Carbapenem
Carbapenem Resistance

Carbapenem Resistance

Antibiotic resistance is fraught and carbapenems are no different. Therefore, there are arising fears in the medical world that hardy and Carbapenem resistant bacteria that are swiftly emerging may cause enough worry for a while. Therefore, owing to this, full-blown research is on to find just the perfect way to combat the resistant bacteria. The good news is that all is not lost because research is ongoing and until you are diagnosed with the antibiotic resistant bacteria, then you have no cause for worry. Little headway has been made and so soon, there will be a solution available in the form of carbapenems. The emergence of the delhi metallo beta lactamase, also called the NDM-l enzyme that is resistant to the carbapenem antibiotics, which are currently the most powerful in the market, is causing worries in the medical fraternity.

The above-mentioned NDM enzyme is notorious in that it renders the antibiotics inactive. It does this because it is coded by loops of DNA that snuggle between bacteria. While such bacteria with the NDM enzymes were largely associated with Asia, they have found their way to many parts of the world now due to people visiting countries and getting hospitalized there. In most cases, patients pick these bacteria in the hospital and that is why carbapenems are said to be active against hospital-acquired bacteria. Medical tourism, which has been on the rise has seen many people seeking specialist medical care and surgery head to the Asian countries like India, Pakistan and Thailand where medical services are very cheap and of high quality, just like in Europe or in America.

Just thinking of there being a drug resistant bacterium sends shivers down the spine. For example, the drug meropenem has been very potent against enterobacteriaceae, H. influenza and many more. Thinking that the same bacteria could now be resistant to the same drug and agent that is supposed to treat them is cause for worry. The emerging strains of bacteria are very deadly and they leave the medical fraternity with no way to combat this deadliness. However, medical researchers all over the world are not taking it easy and so full research is going on round the clock. The bad thing with diseases and discoveries of the cures to heal them is that the disease has to happen fast. So until there started emerging the drug resistant enterobacteriaceae, there was no cause for alarm.

It is important to say that there are still some antibiotics available that show ability to combat NDM enzymes. However, chances are high that soon, bacteria with strains of the same antibiotics will emerge. Therefore, the only hope rests on the carbapenems and therefore a more potent Carbapenem has to be found, one that can combat the bacteria that come with NDM enzyme. All hope in the fight against bacterial infections has been resting on the carbapenems. After all, everything was going just so fine until there started emerging strains of the carbapenems in bacteria in Asia.

There are a few tests performed for gram-negative bacilli. One of them is the Modified Hodge Test where organisms are tested by this method to show positive or negative carbapenem production. If it shows positive, then it means that the organism is in fact resistant to carbapenems and therefore, there will be no treatment for the person carrying such, except perhaps the use of painkillers to make life easier for the patient. Although the strains of Carbapenem resistant bacteria started in Asia, they are fast spreading to the rest of the world. Thus, no one is safe, until a better and more combative Carbapenems for the resistant bacteria can be found.